Focal corticothalamic sources during generalized absence seizures: A MEG study

• Published in: Epilepsy research Vol. 106; no. 1; pp. 113 - 122
• Main Authors: Tenney, Jeffrey R, Fujiwara, Hisako, Horn, Paul S, Jacobson, Sarah E, Glauser, Tracy A, Rose, Douglas F
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.09.2013; Elsevier
• Subjects: Absence seizure; Age of Onset; Algorithms; Beamformer; Biological and medical sciences; Brain Mapping; CAE; Cerebral Cortex - physiopathology; Child; Electroencephalography; Epilepsy, Absence - physiopathology; Epilepsy, Generalized - physiopathology; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Image Processing, Computer-Assisted; Magnetoencephalography; Male; Medical sciences; MEG; Nervous system (semeiology, syndromes); Neurology; sLORETA; Thalamus - physiopathology; Beamformer; sLORETA; Absence seizure; CAE; MEG; Human; Nervous system diseases; Pathophysiology; Magnetoencephalography; Epilepsy; Petit mal; Cerebral disorder; Convulsion; Central nervous system disease; Neurological disorder; Child
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2013.05.006

Highlights • Timing of brain activity during absence seizures is unclear. • MEG was used to determine corticothalamic brain activity during absence seizures. • Before absence seizure onset most activity was seen in frontal cortex and thalamus. • MEG can be used to measure corticothalamic activity with high temporal resolution. • Focal ictal activity occurs during “generalized” childhood absence seizures.