Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia
•Chronic inflammation is one of the hallmarks of sickle cell disease (SCD). We have previously demonstrated that the inflammatory biomarker hs-CRP positively correlated with vaso-occlusive pain in SCD.•In children with SCD, ratios of pro-inflammatory arachidonic acid (AA) to anti-inflammatory docosa...
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Published in | Prostaglandins, leukotrienes and essential fatty acids Vol. 146; pp. 11 - 18 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Scotland
Elsevier Ltd
01.07.2019
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Subjects | |
Online Access | Get full text |
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Summary: | •Chronic inflammation is one of the hallmarks of sickle cell disease (SCD). We have previously demonstrated that the inflammatory biomarker hs-CRP positively correlated with vaso-occlusive pain in SCD.•In children with SCD, ratios of pro-inflammatory arachidonic acid (AA) to anti-inflammatory docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids are increased in red cell phospholipids due to a relative decrease in omega-3 fatty acids.•A relative deficiency of DHA and EPA correlates positively with hs-CRP in children with SCD.•A relative deficiency of DHA and EPA increases with age in children with SCD.
Inflammation and vaso-occlusion play key roles in Sickle Cell Disease (SCD) pathophysiology. Lipoxygenase products of the omega-3 fatty acids (O3FAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are potent anti-inflammatory mediators modulating pain. O3FAs decrease episodes of vaso-occlusion in SCD.
We assessed erythrocyte fatty acid composition in two major cell membrane phospholipids, phosphatidylcholine and phosphatidylethanolamine, in children with SCD HbSS-disease (n = 38) and age/race-matched HbAA-controls (n = 18). Ratio of pro-inflammatory arachidonic acid (AA) to anti-inflammatory DHA and EPA (FA-Ratio), and its relationship to hs-CRP were evaluated.
FA-Ratios were increased in both phosphatidylcholine and phosphatidylethanolamine in HbSS compared to controls. Correlations were noted in HbSS subjects between hs-CRP and FA-Ratios (p = 0.011). FA-Ratios increased with age (p = 0.0007) due to an increase in pro-inflammatory AA with a concomitant decrease in anti-inflammatory DHA.
Findings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Study Design: BNYS, MJS. Enrollment of Study Participants: MM, MC, NL, NA. Laboratory Analysis: BNYS, SGB. Data Analysis: BNYS, MJS. Manuscript Preparation: BNYS, SGB, REM, DSB, MM, MC, NL, NA, MJS. All authors reviewed the manuscript and approved for publication. The authors have no conflict of interest to declare. Author Contribution |
ISSN: | 0952-3278 1532-2823 |
DOI: | 10.1016/j.plefa.2019.05.004 |