Hypoplastic left heart syndrome - unresolved issues

Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that - at best - 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vascul...

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Published inFrontiers in pediatrics Vol. 2; p. 125
Main Authors Arnold, Raoul Roman, Loukanov, Tsvetomir, Gorenflo, Matthias
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.01.2014
Subjects
Assisted Circulation
Heart Failure
HLHS
Pediatrics
right ventricle
univentricular heart
univentricular heart
assisted circulation
heart failure
right ventricle
HLHS
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Summary:Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that - at best - 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vasculature in these patients. In order to further improve long-term prognosis translational research to control RV function, growth of pulmonary arteries and progress in chronic circulatory support are clearly needed to provide a further improvement for adults with HLHS.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Antonio Francesco Corno, University Sains Malaysia, Malaysia
Reviewed by: Yves Durandy, Centre Chirurgical Marie Lannelongue, France; Vladimiro Vida, University of Padua, Italy; Robert Henry Anderson, Newcastle University, UK
This article was submitted to Pediatric Cardiology, a section of the journal Frontiers in Pediatrics.
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2014.00125