Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

[Display omitted] A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 26; no. 4; pp. 1329 - 1332
Main Authors Micheli, Fabrizio, Cremonesi, Susanna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Cavanni, Paolo, Oliosi, Beatrice, Perdonà, Elisabetta, Sava, Anna, Zonzini, Laura, Feriani, Aldo, Braggio, Simone, Heidbreder, Christian
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 15.02.2016
Elsevier
Subjects
7-TM
Animals
Antagonist
Binding Sites
Chemistry
Chemistry, Medicinal
Chemistry, Organic
DA D3 receptor
Dopamine
Dopamine D2 Receptor Antagonists - chemical synthesis
Dopamine D2 Receptor Antagonists - chemistry
Dopamine D2 Receptor Antagonists - pharmacokinetics
Half-Life
Life Sciences & Biomedicine
Molecular Docking Simulation
Morpholine
Morpholines - chemical synthesis
Morpholines - chemistry
Morpholines - pharmacokinetics
Pharmacology & Pharmacy
Physical Sciences
Protein Structure, Tertiary
Rats
Receptors, Dopamine D3 - antagonists & inhibitors
Receptors, Dopamine D3 - metabolism
Science & Technology
Morpholine
DA D3 receptor
Dopamine
Antagonist
7-TM
POTENT
SERIES
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Summary:[Display omitted] A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.12.081