Combinations of genetic data in a study of neuroblastoma risk genotypes

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study...

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Bibliographic Details
Published inCancer genetics Vol. 207; no. 3; pp. 94 - 97
Main Authors Capasso, Mario, Calabrese, Francesco Maria, Iolascon, Achille, Mellerup, Erling
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2014
Subjects
combinations
data mining
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Medical Education
Neuroblastoma
Neuroblastoma - genetics
Polymorphism, Single Nucleotide
SNPs
SNPs
combinations
Neuroblastoma
data mining
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Summary:Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among the latter, a cluster of 24 combinations was found to be significantly associated with NB ( P  < 0.00001).
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ISSN:2210-7762
2210-7770
DOI:10.1016/j.cancergen.2014.02.004