Sensitive determination of phenylephrine and chlorprothixene at poly(4-aminobenzene sulfonic acid) modified glassy carbon electrode

• Published in: Talanta (Oxford) Vol. 74; no. 5; pp. 1435 - 1441
• Main Authors: Huang, Fei, Jin, Guiying, Liu, Yang, Kong, Jilie
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.02.2008; Oxford Elsevier
• Subjects: Analytical chemistry; Antipsychotic Agents - analysis; Carbon; Characterization; Chemistry; Chlorprothixene; Chlorprothixene - analysis; Chromatographic methods and physical methods associated with chromatography; Determination; Electrochemical methods; Exact sciences and technology; Excellent characteristics; Gas chromatographic methods; Microelectrodes - standards; Oxidation-Reduction; Pharmaceutical Preparations; Phenylephrine; Phenylephrine - analysis; Poly(4-amiinozenzene sulfonic acid); Reproducibility of Results; Spectrometric and optical methods; Sulfanilic Acids; Characterization; Poly(4-amiinozenzene sulfonic acid); Determination; Excellent characteristics; Chlorprothixene; Phenylephrine; Drug; Stability; Electrochemical method; Carbon electrode; Selectivity; Buffer solution; Ultraviolet spectrometry; Sulfonic acid; Hydrochloric acid; Gas chromatography; Reproducibility; Detection limit; Tablet
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2007.09.018

Phenylephrine (i.e. PHE) and chlorprothixene (i.e. CPT), two effective and important antipsychotic drugs with low redox activity, were found generating an irreversible anodic peak at about +0.89 V (vs. SCE) and +1.04 V in 0.05 M HAc–NaAc (pH 5.0) or NH 2CH 2COOH–HCl (pH 2.4) buffer solution at poly(4-aminobenzene sulfonic acid) modified glassy carbon electrode (i.e. poly(4-ABSA)/GC), respectively. Sensitive and quantitative measurement for them based on the anodic peaks was established under the optimum conditions. The anodic peak current was linear to PHE and CPT concentrations from 1 × 10 −7 to 1.5 × 10 −5 M and 2 × 10 −6 to 4.5 × 10 −5 M, the detection limits obtained were 1 × 10 −8 and 1 × 10 −7 M, separately. The modified electrode exhibited some excellent characteristics including easy regeneration, high stability, good reproducibility and selectivity. The method proposed was successfully applied to the determination of PHE and CPT in drug injections or tablets and proved to be reliable compared with ultraviolet spectrophotometry. The modified electrode was characterized by electrochemical methods.