How to Improve Cord Blood Engraftment?

Various factors make cord blood (CB) a significant source of hematopoietic stem cells (HSCs), including ease of procurement and lack of donor attrition, with the ability to process and store the donor cells long term. Importantly, high proliferative potential of the immature HSCs allows one log less...

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Bibliographic Details
Published inFrontiers in medicine Vol. 3; p. 7
Main Authors Beksac, Meral, Yurdakul, Pinar
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.02.2016
Subjects
cord blood
Cord blood transplantation
Engraftment
Homing
Medicine
Stem Cells
engraftment
cord blood
homing
cord blood transplantation
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Summary:Various factors make cord blood (CB) a significant source of hematopoietic stem cells (HSCs), including ease of procurement and lack of donor attrition, with the ability to process and store the donor cells long term. Importantly, high proliferative potential of the immature HSCs allows one log less use of cells compared to bone marrow or peripheral blood stem cells. As total nucleated cell (TNC) and CD34(+) cell content of CB grafts are correlated to engraftment rate and speed, strategies to expand HSC and homing have been developed. This chapter will focus only on modalities such as intrabone administration, fucosylation, CD26 inhibition, prostaglandin E2 derivative or complement 3 exposure, and SDF-1/CXCR4/CXCL-12 pathway interventions that have been experimented successfully. Furthermore, increasing evidence in line with better recognition of CB progenitors that are involved in engraftment and homing will also be addressed.
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Edited by: Alvin H. Schmaier, Case Western Reserve University and University Hospitals Case Medical Center, USA
Specialty section: This article was submitted to Hematology, a section of the journal Frontiers in Medicine
Reviewed by: Owen McCarty, Oregon Health & Science University, USA; Mary Joan Laughlin, Cleveland Cord Blood Center, USA
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2016.00007