Concomitant surgical ablation for atrial fibrillation is associated with increased risk of acute kidney injury but improved late survival

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 164; no. 6; pp. 1847 - 1857.e3
• Main Authors: Bakir, Nadia H., Khiabani, Ali J., MacGregor, Robert M., Kelly, Meghan O., Sinn, Laurie A., Schuessler, Richard B., Maniar, Hersh S., Melby, Spencer J., Helwani, Mohammad A., Damiano, Ralph J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2022
• Subjects: acute kidney injury; Acute Kidney Injury - epidemiology; Atrial Fibrillation - complications; Atrial Fibrillation - surgery; Cox-Maze IV procedure; dialysis; Humans; Postoperative Complications; propensity score match; Renal Dialysis - adverse effects; renal failure; Retrospective Studies; Risk Factors; surgical ablation; Treatment Outcome; dialysis; propensity score match; CMP-IV; OR; AF; CI; Cox-Maze IV procedure; LAA; GFR; STS; CPB; RF; surgical ablation; renal failure; KDIGO; acute kidney injury; AKI
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1016/j.jtcvs.2021.01.023

Acute kidney injury (AKI) after cardiac surgery remains a common complication that has been associated with increased morbidity and mortality. This study implemented Kidney Disease Improving Global Outcomes criteria to evaluate renal outcomes after concomitant surgical ablation for atrial fibrillation. Patients with a history of atrial fibrillation who underwent elective cardiac surgery at our institution from 2008 to 2018 were retrospectively reviewed. Those with preoperative renal dysfunction were excluded. Patients were classified as those who underwent concomitant Cox-Maze IV (CMP-IV) (n = 376) or no surgical ablation (n = 498). Nearest neighbor 1:1 propensity matching was conducted on fourteen covariates. AKI was evaluated by mixed effects logistic regression analysis. Long-term survival was evaluated by proportional hazards regression. Propensity matching yielded 308 patients in each group (n = 616). All preoperative variables were similar between groups. The concomitant CMP-IV group had a greater incidence of AKI: 32% (n = 99) versus 16% (n = 49), P < .001. After accounting for bypass time and nonablation operations on mixed effects analysis, concomitant CMP-IV was associated with increased risk of AKI (odds ratio, 1.89; confidence interval, 1.12-3.18; P = .017). While AKI was associated with decreased late survival (P < .001), patients who received a concomitant CMP-IV maintained superior 7-year survival to patients who received no ablation (P < .001). No patients required permanent dialysis. Concomitant CMP-IV was independently associated with increased risk of AKI in the acute postoperative period. However, the long-term risks of AKI were offset by the significant survival benefit of CMP-IV. Concerns regarding new-onset renal dysfunction should not prohibit recommendation of this procedure in appropriate patients. [Display omitted]