Platelet Function in Aging

Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular d...

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Published inFrontiers in cardiovascular medicine Vol. 6; p. 109
Main Authors Le Blanc, Jessica, Lordkipanidzé, Marie
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.08.2019
Subjects
aging
cardiovascular disease
Cardiovascular Medicine
elderly
platelet function
senescence
thrombosis
senescence
cardiovascular disease
thrombosis
aging
platelet function
elderly
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Summary:Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
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Edited by: Christian Schulz, Ludwig Maximilian University of Munich, Germany
Reviewed by: John Hwa, School of Medicine, Yale University, United States; Andres Trostchansky, University of the Republic, Uruguay
This article was submitted to Atherosclerosis and Vascular Medicine, a section of the journal Frontiers in Cardiovascular Medicine
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2019.00109