Controllable construction of Titanium dioxide-Zirconium dioxide@Zinc hydroxyfluoride networks in micro-capillaries for bio-analysis

• Published in: Journal of colloid and interface science Vol. 446; pp. 290 - 297
• Main Authors: Wang, Gang, He, Zhongyuan, Shi, Guoying, Wang, Hongzhi, Zhang, Qinghong, Li, Yaogang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2015
• Subjects: 3D network; Animals; Cancer serum; Cattle; Colorectal Neoplasms - blood; Electrophoresis, Capillary - instrumentation; Electrophoresis, Capillary - methods; Enhanced mixing; Fluorides - chemistry; Glass - chemistry; Humans; Microfluidic technology; Milk - chemistry; Phosphopeptides - analysis; Silicon Dioxide - chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Titanium - chemistry; Zinc - chemistry; Zirconium - chemistry; Enhanced mixing; 3D network; Microfluidic technology; Cancer serum
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2015.01.048

[Display omitted] Glass/silica-based flow channels are widely used in capillary electrophoresis and micro-total analysis systems. However, it is almost impossible to achieve controllable fabrication of microstructures with enhanced mixing performance for high-efficiency bio-analysis in confined micro-channels. Here, various morphologies were controllably achieved by tuning the molar ratio of the reaction agents in a confined microchannel. Fluid flow simulation is demonstrated to investigate the structure stability and mixing performance. Multifunctional networks with uniform and deep decoration are fabricated in confined micro-capillaries, owing to the enhanced mixing performance. The modified micro-capillaries exhibit high efficiencies for the selective enrichment of phosphopeptides from traditional model samples. Furthermore, the fabricated micro-capillaries also exhibited high performance in practical applications (for selective enrichments from bovine milk and cancer serum). These outstanding features make the microstructure-modified micro-capillaries promising for bio-analysis.