Nocturia as an Unrecognized Symptom of Uncontrolled Hypertension in Black Men Aged 35 to 49 Years

• Published in: Journal of the American Heart Association Vol. 8; no. 5; p. e010794
• Main Authors: Victor, Ronald G, Li, Ning, Blyler, Ciantel A, Mason, O'Neil R, Chang, L Cindy, Moy, Norma Priscilla B, Rashid, Mohammad A, Weiss, Jeffrey P, Handler, Joel, Brettler, Jeffrey W, Sagisi, Michael B, Rader, Florian, Elashoff, Robert M
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 05.03.2019; Wiley
• Subjects: Adult; African Americans; Aged; Barbering; Blood Pressure; California - epidemiology; Community Health Services; Comorbidity; Cross-Sectional Studies; Health Status; high blood pressure; Humans; hypertension; Hypertension - diagnosis; Hypertension - ethnology; Hypertension - physiopathology; Male; Middle Aged; nocturia; Nocturia - diagnosis; Nocturia - ethnology; Nocturia - physiopathology; Original Research; Prevalence; Randomized Controlled Trials as Topic; Risk Factors; Urodynamics; California; nocturia; hypertension; high blood pressure
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.118.010794

Background Hypertension is assumed to be asymptomatic. Yet, clinically significant nocturia (≥2 nightly voids) constitutes a putative symptom of uncontrolled hypertension. Black men with hypertension may be prone to nocturia because of blunted nocturnal blood pressure ( BP ) dipping, diuretic drug use for hypertension, and comorbidity that predisposes to nocturia. Here, we test the hypothesis that nocturia is a common and potentially reversible symptom of uncontrolled hypertension in black men. Methods and Results We determined the strength of association between nocturia (≥2 nightly voids) and high BP (≥135/85 mm Hg) by conducting in-person health interviews and measuring BP with an automated monitor in a large community-based sample of black men in their barbershops. Because nocturia is prevalent and steeply age-dependent after age 50 years, we studied men aged 35 to 49 years. Among 1673 black men (mean age, 43±4 years [ SD ]), those with hypertension were 56% more likely than men with normotension to have nocturia after adjustment for diabetes mellitus and sleep apnea (adjusted odds ratio, 1.56; 95% CI , 1.25-1.94 [ P<0.0001]). Nocturia prevalence varied by hypertension status, ranging from 24% in men with normotension to 49% in men whose hypertension was medically treated but uncontrolled. Men with untreated hypertension were 39% more likely than men with normotension to report nocturia ( P=0.02), whereas men whose hypertension was treated and controlled were no more likely than men with normotension to report nocturia ( P=0.69). Conclusions Uncontrolled hypertension was an independent determinant of clinically important nocturia in a large cross-sectional community-based study of non-Hispanic black men aged 35 to 49 years. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unqiue identifier: NCT 02321618.