The effect of transdermal oestradiol on bleeding pattern, hormonal profiles and sex steroid receptor distribution in the endometrium of Norplant users

• Published in: Human reproduction (Oxford) Vol. 11; no. suppl-2; pp. 115 - 123
• Main Authors: Boonkasemsanti, Wisut, Reinprayoon, Damrong, Pruksananonda, Kamthorn, Niruttisard, Somchai, Triratanachat, Surang, Leepipatpaiboon, Smai, Wannakrairot, Pongsak
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Oxford University Press 01.10.1996
• Subjects: Administration, Cutaneous; Biological and medical sciences; Biopsy; Birth control; Contraceptive Agents, Female - adverse effects; Contraceptive Agents, Female - blood; Contraceptive Agents, Female - metabolism; endometrium; Endometrium - chemistry; Endometrium - drug effects; Endometrium - pathology; Estradiol - administration & dosage; Estradiol - pharmacology; Estrogens - blood; Estrogens - metabolism; Female; Gynecology. Andrology. Obstetrics; Hormonal contraception; Humans; Immunohistochemistry; Levonorgestrel - adverse effects; Levonorgestrel - blood; Levonorgestrel - metabolism; Medical sciences; Norplant; Progesterone - blood; Progesterone - metabolism; Receptors, Estrogen - analysis; Receptors, Estrogen - immunology; Receptors, Progesterone - analysis; Receptors, Progesterone - immunology; Receptors, Steroid - analysis; Receptors, Steroid - immunology; Sex Hormone-Binding Globulin - drug effects; Sex Hormone-Binding Globulin - metabolism; steroid receptors; transdermal oestradiol; Uterine Hemorrhage - blood; Uterine Hemorrhage - drug therapy; endometrium; immunohistochemistry; steroid receptors; transdermal oestradiol; Norplant; Human; Menstruation disorders; Transdermal system; Implant; Toxicity; Estradiol; Hemorrhage; Female genital diseases; Progestagen; Prevention; Female; Subcutaneous administration; Contraceptive; Sex steroid hormone; Endometrium; Hormonal receptor; Comparative Studies; Contraceptive Agents > pharmacodynamics; Estrogens; Endometrial Effects; Hormone Receptors; Biology; Hormones; Research Methodology; Thailand; Urogenital System; Contraceptive Agents > side effects; Clinical Research; Uterus; Research Report; Physiology; Levonorgestrel > pharmacodynamics; Contraceptive Implants > side effects; Genitalia; Contraceptive Agents, Female > pharmacodynamics; Contraception; Contraceptive Methods > side effects; Estradiol > therapeutic use; Family Planning; Endocrine System; Genitalia, Female; Diseases; Membrane Proteins; Menstruation Disorders; Studies; Treatment; Asia; Southeastern Asia; Contraceptive Agents, Progestin > side effects; Developing Countries; Contraceptive Agents, Female > side effects
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/11.suppl_2.115

The most common side-effect and reason for discontinuation with Norplant use is bleeding disturbance. The aim of this study was to investigate whether the 6 week application of a patch which released 100 μg/day oestradiol would reduce the number of abnormal bleeding days or eliminate the problem. Another objective was to find out the correlation between the bleeding pattern and endometrial concentrations of oestrogen receptor (ER) and progesterone receptor (PR). Of 98 Norplant users, 34 patients had normal bleeding patterns and 64 patients had abnormal bleeding patterns. An oestradiol patch or a placebo patch were randomly used to treat 33 and 31 women with abnormal bleeding respectively. There was a clinical improvement in the oestradiol group compared with the placebo group, although this was not statistically significant There were no correlations between PR and ER concentration and the serum oestradiol, progesterone, levonorgestrel and sex hormone-binding globulin concentrations. Significantly increased mean immunostaining scores of stromal PR were observed in those Norplant users whose endometrium had an atrophic histological appearance. The serum oestradiol concentration did not show a significant change after treatment with the oestradiol patch compared with the placebo patch.