Polyphosphate as a Target for Interference With Inflammation and Thrombosis

Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. Pol...

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Bibliographic Details
Published inFrontiers in medicine Vol. 6; p. 76
Main Authors Mailer, Reiner K W, Hänel, Lorena, Allende, Mikel, Renné, Thomas
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 12.04.2019
Subjects
coagulation
factor XII
hereditary angioedema
inflammation
Medicine
polyphosphate
thrombosis
polyphosphate
hereditary angioedema
thrombosis
inflammation
immune activation
vascular permeability
coagulation
factor XII
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Summary:Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Reviewed by: Wei Li, Marshall University, United States; Brian R. Branchford, University of Colorado Denver, United States
Edited by: Keith McCrae, Cleveland Clinic, United States
This article was submitted to Hematology, a section of the journal Frontiers in Medicine
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2019.00076