Mitochondrial sirtuins in stem cells and cancer

The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and SIRT5) localise specifically within mitochondria and preserve mitochondrial function and homeostasis. Mitochondrial sirtuins are involved in diverse functions such as deacetylation, ADP‐ribosylation, demalonyl...

Full description

Saved in:
Bibliographic Details
Published inThe FEBS journal Vol. 289; no. 12; pp. 3393 - 3415
Main Authors Jaiswal, Amit, Xudong, Zhu, Zhenyu, Ju, Saretzki, Gabriele
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.06.2022
Subjects
Adenosine diphosphate
Cancer
Cell fate
Crosstalk
Deacetylation
Homeostasis
Medical treatment
Mitochondria
Ribosylation
Signal transduction
SIRT3
SIRT4
SIRT5
Sirtuins
Stem cells
Structure-function relationships
Substrates
stem cells
mitochondria
sirtuins
SIRT4
SIRT5
cancer
SIRT3
Online AccessGet full text

Cover

More Information
Summary:The mammalian sirtuin family consists of seven proteins, three of which (SIRT3, SIRT4, and SIRT5) localise specifically within mitochondria and preserve mitochondrial function and homeostasis. Mitochondrial sirtuins are involved in diverse functions such as deacetylation, ADP‐ribosylation, demalonylation and desuccinylation, thus affecting various aspects of cell fate. Intriguingly, mitochondrial sirtuins are able to manage these delicate processes with accuracy mediated by crosstalk between the nucleus and mitochondria. Previous studies have provided ample information about their substrates and targets, whereas less is known about their role in cancer and stem cells. Here, we review and discuss recent advances in our understanding of the structural and functional properties of mitochondrial sirtuins, including their targets in cancer and stem cells. These advances could help to improve the understanding of their interplay with signalling cascades and pathways, leading to new avenues for developing novel drugs for sirtuin‐related disease treatments. We also highlight the complex network of mitochondrial sirtuins in cancer and stem cells, which may be important in deciphering the molecular mechanism for their activation and inhibition. Mitochondrial sirtuins consist of three members – SIRT3, SIRT4 and SIRT5. They perform various post‐translational modifications in order to preserve mitochondrial function and homeostasis. They are involved in apoptosis and can change energy metabolism of cells contributing to alterations of energy substrate usage in stem and cancer cells. In this review, we summarise structural and functional properties of mitochondrial sirtuins and their role in stem and cancer cells. ​
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1742-464X
1742-4658
DOI:10.1111/febs.15879