The Interaction Network and Signaling Specificity of Two-Component System in Arabidopsis

• Published in: International journal of molecular sciences Vol. 21; no. 14; p. 4898
• Main Authors: Huo, Ruxue, Liu, Zhenning, Yu, Xiaolin, Li, Zongyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.07.2020; MDPI
• Subjects: Alkyl and Aryl Transferases - genetics; Alkyl and Aryl Transferases - physiology; Arabidopsis; Arabidopsis - genetics; Arabidopsis - physiology; Cell division; Gene expression; Gene Expression Regulation, Plant; Genomes; Histidine; Histidine Kinase - genetics; Histidine Kinase - physiology; histidine kinases; histidine-containing phosphotransfer proteins; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - physiology; Kinases; Magnesium - metabolism; Models, Biological; Molecular modelling; mRNA; multi-step phosphorelay; Multigene Family; Mutation; Phosphates - metabolism; Phosphorylation; Phosphotransferases - genetics; Phosphotransferases - physiology; Phytochrome - physiology; Plant Proteins - genetics; Plant Proteins - physiology; Prokaryotes; Protein Binding; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps - physiology; Protein Processing, Post-Translational; Proteins; protein–protein interaction network; Proteolysis; Regulators; response regulators; Review; RNA, Messenger - genetics; RNA, Plant - genetics; Seeds; Senescence; Signal transduction; Signal Transduction - genetics; Signal Transduction - physiology; two-component system; histidine-containing phosphotransfer proteins; signaling specificity; multi-step phosphorelay; response regulators; protein–protein interaction network; histidine kinases; two-component system
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21144898

Two-component systems (TCS) in plants have evolved into a more complicated multi-step phosphorelay (MSP) pathway, which employs histidine kinases (HKs), histidine-containing phosphotransfer proteins (HPts), and response regulators (RRs) to regulate various aspects of plant growth and development. How plants perceive the external signals, then integrate and transduce the secondary signals specifically to the desired destination, is a fundamental characteristic of the MSP signaling network. The TCS elements involved in the MSP pathway and molecular mechanisms of signal transduction have been best understood in the model plant . In this review, we focus on updated knowledge on TCS signal transduction in . We first present a brief description of the TCS elements; then, the protein-protein interaction network is established. Finally, we discuss the possible molecular mechanisms involved in the specificity of the MSP signaling at the mRNA and protein levels.