Evaluation of changes in tidal volume during mask ventilation following administration of neuromuscular blocking drugs

Summary The practice of checking the ability to mask ventilate before administering neuromuscular blocking drugs remains controversial. We prospectively evaluated the changes in the expired tidal volume during pressure‐controlled ventilation (two‐handed mask ventilation technique) as a surrogate mar...

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Published inAnaesthesia Vol. 69; no. 8; pp. 826 - 831
Main Authors Sachdeva, R., Kannan, T. R., Mendonca, C., Patteril, M.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.08.2014
Subjects
Adult
Aged
Androstanols - pharmacology
Anesthesia
Body Mass Index
Female
Humans
Male
Masks
Middle Aged
Neuromuscular Nondepolarizing Agents - pharmacology
Prospective Studies
Rocuronium
Tidal Volume - drug effects
Ventilation
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Summary:Summary The practice of checking the ability to mask ventilate before administering neuromuscular blocking drugs remains controversial. We prospectively evaluated the changes in the expired tidal volume during pressure‐controlled ventilation (two‐handed mask ventilation technique) as a surrogate marker to assess the ease of mask ventilation following administration of rocuronium. After informed consent, 125 patients were anaesthetised using a standard induction technique consisting of fentanyl, propofol and rocuronium, with anaesthesia then maintained with isoflurane in oxygen. The mean (SD) expired tidal volume before administration of rocuronium increased by 61 (13) ml at 2 min following onset of neuromuscular block (p < 0.001). This supports the concept that neuromuscular blockade induced by rocuronium facilitates mask ventilation.
Bibliography:http://www.anaesthesiacorrespondence.com
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-2409
1365-2044
DOI:10.1111/anae.12677