Diet-induced weight loss in obese children with asthma: a randomized controlled trial
Summary Background Obesity is highly prevalent in asthmatic children and associated with worse clinical outcomes. Energy restriction to induce weight loss in asthmatic children has not been investigated in a randomized controlled trial (RCT). Objective To assess if (1) weight loss can be achieved in...
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Published in | Clinical and experimental allergy Vol. 43; no. 7; pp. 775 - 784 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.07.2013
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
Background
Obesity is highly prevalent in asthmatic children and associated with worse clinical outcomes. Energy restriction to induce weight loss in asthmatic children has not been investigated in a randomized controlled trial (RCT).
Objective
To assess if (1) weight loss can be achieved in obese asthmatic children using a dietary intervention; and (2) changes in asthma outcomes occur following diet‐induced weight loss.
Methods
In a 10‐week pilot RCT, obese asthmatic children, aged 8–17 years, were randomized to a wait‐list control (WLC) (n = 15) or dietary‐intervention group (DIG) (n = 13). Lung function, Asthma Control Questionnaire (ACQ) score, and sputum and systemic inflammation were assessed at baseline and post‐intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000955011).
Results
Body mass index (BMI) z‐score reduced significantly in the DIG vs. the WLC (−0.2 [−0.4, −0.1] vs. 0.0 [−0.1, 0.0], P = 0.014). Expiratory reserve volume (ERV) increased significantly within the DIG, but not compared to the WLC (0.7 [0.0, 1.0] L vs. 0.3 [0.0, 0.8] L, P = 0.355). ACQ improved significantly in the DIG, compared to the WLC (−0.4 [−0.7, 0.0] vs. 0.1 [0.0, 0.6], P = 0.004). Airway and systemic inflammation did not change within the DIG. In comparison, C‐Reactive Protein (CRP) increased significantly in the WLC (−0.4 [−0.5, 0.4] vs. 0.7 [−0.1, 1.9], P = 0.037). Change (∆) in BMI z‐score correlated with ∆CRP (r = 0.47, P = 0.012) and ∆exhaled nitric oxide (eNO) (r = 0.46, P = 0.034), and ∆ACQ was associated with ∆CRP (r = 0.43, P = 0.029).
Conclusion and Clinical Relevance
Dietary intervention can induce acute weight loss in obese asthmatic children with subsequent improvements in static lung function and asthma control. Systemic and airway inflammation did not change following weight loss. However, changes in BMI z‐score were associated with changes in airway and systemic inflammation and this requires further investigation in a larger RCT. This is the first weight loss RCT conducted in obese asthmatic children. Diet‐induced weight loss can achieve significant improvements in clinical outcomes for obese children with asthma. |
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Bibliography: | Hunter Medical Research Institute Gastronomic Society Donor Grant ark:/67375/WNG-8HNNVC6P-V University of Newcastle Priority Research Centre ArticleID:CEA12115 Australian National Health and Medical Research Council Career Development Fellowship istex:0E9126EF9FB9649852CE68B6210FF5CA8FFDC210 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0954-7894 1365-2222 |
DOI: | 10.1111/cea.12115 |