Divergent Roles of Autophagy in Virus Infection

Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for...

Full description

Saved in:
Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 2; no. 1; pp. 83 - 104
Main Authors Chiramel, Abhilash, Brady, Nathan, Bartenschlager, Ralf
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 25.01.2013
MDPI
Subjects
antiviral and proviral autophagy
Review
selectively autophagy
virophagy
Online AccessGet full text

Cover

More Information
Summary:Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens, viruses exploit and manipulate different host cell processes, including cellular trafficking, metabolism and immunity-related functions, for their own survival. In this article, we review evidence for how autophagy, a highly conserved cellular degradative pathway, serves either as an antiviral defense mechanism or, alternatively, as a pro-viral process during virus infection. Furthermore, we highlight recent reports concerning the role of selective autophagy in virus infection and how viruses manipulate autophagy to evade lysosomal capture and degradation.
Bibliography:content type line 1
SourceType-Scholarly Journals-1
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:2073-4409
2073-4409
DOI:10.3390/cells2010083