Future developments: In vitro growth (IVG) of human ovarian follicles

Removal and storage of ovarian cortical tissue is currently offered to young female cancer patients undergoing potentially sterilizing chemotherapy and/or radiotherapy. For patients at high risk of reintroduction of malignancy through auto‐transplantation, the ultimate aim is to achieve complete ooc...

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Bibliographic Details
Published inActa obstetricia et gynecologica Scandinavica Vol. 98; no. 5; pp. 653 - 658
Main Author Telfer, Evelyn E.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.05.2019
Subjects
Female
Fertility
Fertility Preservation - methods
follicle culture
Gynecology
Humans
in vitro activation
in vitro growth
in vitro maturation
In Vitro Oocyte Maturation Techniques - methods
In Vitro Oocyte Maturation Techniques - trends
Infertility, Female - chemically induced
Infertility, Female - therapy
Medical research
oocyte
Ovarian Follicle - physiology
primordial follicles
Reproductive technologies
Rodents
in vitro growth
in vitro maturation
follicle culture
oocyte
in vitro activation
primordial follicles
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Summary:Removal and storage of ovarian cortical tissue is currently offered to young female cancer patients undergoing potentially sterilizing chemotherapy and/or radiotherapy. For patients at high risk of reintroduction of malignancy through auto‐transplantation, the ultimate aim is to achieve complete oocyte development from this tissue in vitro. The ability to develop human oocytes from the earliest follicular stages through to maturation and fertilization in vitro would revolutionize fertility preservation practice. This has been achieved in mice where in vitro grown oocytes from primordial follicles have resulted in the production of live offspring. Systems that support growth and development of oocytes from human ovarian cortex are being developed by several groups. This review focuses on the steps required to recapitulate in vitro the process of human oocyte development from the primordial stage and the systems currently available to support this.
Bibliography:Funding information
Work relating to this area in the Telfer laboratory has been funded by the Medical Research Council.
ISSN:0001-6349
1600-0412
DOI:10.1111/aogs.13592