Maltobionic acid enhances intestinal absorption of calcium and magnesium in rats

• Published in: Bioscience, biotechnology, and biochemistry Vol. 83; no. 9; pp. 1766 - 1773
• Main Authors: Suehiro, Daiki, Okada, Misato, Fukami, Ken, Nakagawa, Tomoyuki, Hayakawa, Takashi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.09.2019; Oxford University Press
• Subjects: calcium absorption; calcium maltobionate; magnesium absorption; Maltobionic acid; oligosacchaide; calcium maltobionate; Maltobionic acid; calcium absorption; magnesium absorption; oligosacchaide
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1080/09168451.2019.1611411

In Experiment 1, the effects of calcium maltobionate (MBCa) on calcium and magnesium absorption were examined using male rats. Four diets were designed in which 25%, 50%, and 100% of calcium carbonate (CaCO 3 , Control) were substituted with MBCa and were designated as MBCa-25, MBCa-50, and MBCa-100, respectively. The cecal concentration of short-chain fatty acids was significantly higher in groups MBCa-50 and MBCa-100; however, pH of cecal contents did not significantly differ among the groups. Retention rates of calcium and magnesium were significantly higher in all MBCa groups as compared to the Control. In Experiment 2, the efficiency of calcium absorption was compared using everted sacs of jejunum and ileum with CaCO 3 and MBCa as calcium sources. More calcium from MBCa was absorbed as the concentration of calcium increased in comparison to CaCO 3 . It was concluded that MBCa is a better calcium source than CaCO 3 in terms of both calcium retention and absorption. Abbreviations: ANOVA: analysis of variance; Ca: Calcium; CaCO 3: calcium carbonate; ICP-OES: Inductivity coupled plasma optical emission spectrometer; Mg: magnesium; MBCa: calcium maltobionate; OCPC: o-cresolphthalein complexone; SCFAs: short-chain fatty acids; SE: standard error; TRPM6: transient receptor potential melastatin 6. Calcium carbonate was substituted with calcium maltobionate (MBCa) at 25, 50 and 100% based on calcium equivalency. Absorption of Ca (a)　and Mg (b) was significantly higher in MB-Ca diet groups as compared to　the control group.