Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real‐time phase‐contrast MRI

• Published in: Journal of magnetic resonance imaging Vol. 46; no. 2; pp. 431 - 439
• Main Authors: Yildiz, Selda, Thyagaraj, Suraj, Jin, Ning, Zhong, Xiaodong, Heidari Pahlavian, Soroush, Martin, Bryn A., Loth, Francis, Oshinski, John, Sabra, Karim G.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2017
• Subjects: Adult; Breathing; cardiac; Cerebrospinal Fluid; Computational fluid dynamics; Computer Simulation; Contrast Media; coughing; CSF flow velocity; Female; Fluid dynamics; Foramen Magnum; Healthy Volunteers; Heart; Heart - diagnostic imaging; Heart diseases; Heart Rate; Humans; Hydrodynamics; Image Processing, Computer-Assisted; In vitro methods and tests; Magnetic Resonance Imaging; Male; Microscopy, Phase-Contrast; Middle Aged; Mimicry; NMR; Nuclear magnetic resonance; Phantoms, Imaging; Phase contrast; Pulsatile Flow; Real time; real‐time phase contrast MRI; Reproducibility of Results; Respiration; Signal Processing, Computer-Assisted; Software; Subarachnoid Space; Supine Position; Velocity; Waveforms; Young Adult; CSF flow velocity; real-time phase contrast MRI; respiration; coughing; cerebrospinal fluid; cardiac
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.25591

Purpose To validate a real‐time phase contrast magnetic resonance imaging (RT‐PCMRI) sequence in a controlled phantom model, and to quantify the relative contributions of respiration and cardiac pulsations on cerebrospinal fluid (CSF) velocity at the level of the foramen magnum (FM). Materials and Methods To validate the 3T MRI techniques, in vitro studies used a realistic model of the spinal subarachnoid space driven by pulsatile flow waveforms mimicking the respiratory and cardiac components of CSF flow. Subsequently, CSF flow was measured continuously during 1‐minute RT‐PCMRI acquisitions at the FM while healthy subjects (N = 20) performed natural breathing, deep breathing, breath‐holding, and coughing. Conventional cardiac‐gated PCMRI was obtained for comparison. A frequency domain power ratio analysis determined the relative contribution of respiration versus cardiac ([r/c]) components of CSF velocity. Results In vitro studies demonstrating the accuracy of RT‐PCMRI within 5% of input values showed that conventional PCMRI measures only the cardiac component of CSF velocity (0.42 ± 0.02 cm/s), averages out respiratory effects, and underestimates the magnitude of CSF velocity (0.96 ± 0.07 cm/s). In vivo RT‐PCMRI measurements indicated the ratio of respiratory to cardiac velocity pulsations averaged over all subjects as [r/c = 0.14 ± 0.27] and [r/c = 0.40 ± 0.47] for natural and deep breathing, respectively. During coughing, the peak CSF velocity increased by a factor of 2.27 ± 1.40. Conclusion RT‐PCMRI can noninvasively measure instantaneous CSF velocity driven by cardiac pulsations, respiration, and coughing in real time. A comparable contribution of respiration and cardiac pulsations on CSF velocity was found during deep breathing but not during natural breathing. Level of Evidence: 1 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:431–439