Regulation of melanocyte stem cell behavior by the niche microenvironment

Summary Somatic stem cells are regulated by their niches to maintain tissue homeostasis and repair throughout the lifetime of an organism. An excellent example to study stem cell/niche interactions is provided by the regeneration of melanocytes during the hair cycle and in response to various types...

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Published inPigment cell and melanoma research Vol. 31; no. 5; pp. 556 - 569
Main Authors Li, Huirong, Hou, Ling
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.09.2018
Subjects
cell–cell interaction
Crosstalk
Genotoxicity
Homeostasis
intrinsic factors
Melanocytes
Regeneration
self‐maintenance
Signaling
signaling pathways
stem cell niche
Stem cells
Wnt protein
stem cell niche
signaling pathways
self-maintenance
cell-cell interaction
intrinsic factors
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Summary:Summary Somatic stem cells are regulated by their niches to maintain tissue homeostasis and repair throughout the lifetime of an organism. An excellent example to study stem cell/niche interactions is provided by the regeneration of melanocytes during the hair cycle and in response to various types of injury. These processes are regulated by neighboring stem cells and multiple signaling pathways, including WNT/β‐catenin, KITL/KIT, EDNs/EDNRB, TGF‐β/TGF‐βR, α‐MSH/MC1R, and Notch signaling. In this review, we highlight recent studies that have advanced our understanding of the molecular crosstalk between melanocyte stem cells and their neighboring cells, which collectively form the niche microenvironment, and we focus on the question of how McSCs/niche interactions shape the responses to genotoxic damages and mechanical injury.
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ISSN:1755-1471
1755-148X
DOI:10.1111/pcmr.12701