Prefrontal mediation of emotion regulation in social anxiety disorder during laughter perception

• Published in: Neuropsychologia Vol. 96; pp. 175 - 183
• Main Authors: Kreifelts, Benjamin, Brück, Carolin, Ethofer, Thomas, Ritter, Jan, Weigel, Lena, Erb, Michael, Wildgruber, Dirk
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2017
• Subjects: Acoustic Stimulation; Adult; Analysis of Variance; Bias; Cues; Dorsolateral prefrontal cortex; Female; FMRI; Functional Laterality; Humans; Image Processing, Computer-Assisted; Interpretation bias; Laughter; Magnetic Resonance Imaging; Male; Mediation analysis; Oxygen - blood; Phobia, Social - diagnostic imaging; Phobia, Social - pathology; Phobia, Social - psychology; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Psychiatric Status Rating Scales; Psychometrics; Reaction Time - physiology; Reappraisal; Social Perception; Young Adult; Dorsolateral prefrontal cortex; Laughter; Interpretation bias; Reappraisal; Mediation analysis; FMRI
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2017.01.016

Social anxiety disorder (SAD) is characterized by negatively biased perception of social cues and deficits in emotion regulation. While negatively biased perception is thought to maintain social anxiety, emotion regulation represents an ability necessary to overcome both biased perception and social anxiety. Here, we used laughter as a social threat in a functional magnetic resonance imaging (fMRI) study to identify cerebral mediators linking SAD with attention and interpretation biases and their modification through cognitive emotion regulation in the form of reappraisal. We found that reappraisal abolished the negative laughter interpretation bias in SAD and that this process was directly mediated through activation patterns of the left dorsolateral prefrontal cortex (DLPFC) serving as a cerebral pivot between biased social perception and its normalization through reappraisal. Connectivity analyses revealed reduced prefrontal control over threat-processing sensory cortices (here: the temporal voice area) during cognitive emotion regulation in SAD. Our results indicate a central role for the left DLPFC in SAD which might represent a valuable target for future research on interventions either aiming to directly modulate cognitive emotion regulation in SAD or to evaluate its potential as physiological marker for psychotherapeutic interventions relying on emotion regulation. •Negative cognitive biases occur in social anxiety disorder during laughter perception.•Emotion regulation through reappraisal abolishes this laughter perception bias.•FMRI activation of the prefrontal cortex mediates this positive effect of reappraisal.