Impact of Oxidative Stress on Molecular Mechanisms of Cervical Ripening in Pregnant Women

Uterine cervix is one of the essential factors in labor and maintaining the proper course of pregnancy. During the last days of gestation, the cervix undergoes extensive changes manifested by transformation from a tight and rigid to one that is soft and able to dilate. These changes can be summarize...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 23; no. 21; p. 12780
Main Authors Socha, Maciej W., Flis, Wojciech, Wartęga, Mateusz, Stankiewicz, Martyna
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2022
MDPI
Subjects
Antioxidants
cervical ripening
Cervix
Collagen
Connective tissue
Cytochrome
Endoplasmic reticulum
Enzymes
Extracellular matrix
Fetuses
Free radicals
Gestation
Heparan sulfate
Homeostasis
Hyaluronic acid
Inflammation
Intracellular signalling
Kinases
Molecular modelling
Nitric oxide
Nitrogen dioxide
Oxidation
Oxidative stress
Phosphorylation
Physiology
Pregnancy
Proteins
reactive nitrogen species
reactive oxygen species
Review
Ripening
RNS
ROS
Second messengers
Smooth muscle
Uterus
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Summary:Uterine cervix is one of the essential factors in labor and maintaining the proper course of pregnancy. During the last days of gestation, the cervix undergoes extensive changes manifested by transformation from a tight and rigid to one that is soft and able to dilate. These changes can be summarized as “cervical ripening”. Changes in the cervical tissue can be referred to as remodeling of the extracellular matrix. The entire process is the result of a close relationship between biochemical and molecular pathways, which is strictly controlled by inflammatory and endocrine factors. When the production of reactive oxygen species exceeds the antioxidant capacity, oxidative stress occurs. A physiologic increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is observed through pregnancy. ROS play important roles as second messengers in many intracellular signaling cascades contributing to the course of gestation. This review considers their involvement in the cervical ripening process, emphasizing the molecular and biochemical pathways and the clinical implications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232112780