Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity

Evidence exists for a role for vitamin D and its active metabolites in modulating immune functions. In animal models, vitamin D deficiency is associated with a higher risk for autoimmunity in genetically predisposed subjects and increases in susceptibility to infections. In addition, high-dose vitam...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 46; no. 4; p. 1061
Main Authors Vanherwegen, An-Sofie, Gysemans, Conny, Mathieu, Chantal
Format Journal Article
LanguageEnglish
Published United States 01.12.2017
Subjects
Animals
Autoimmunity - drug effects
Cholecalciferol - administration & dosage
Cholecalciferol - therapeutic use
Dietary Supplements
Humans
Leukocytes - drug effects
Leukocytes - immunology
Macrophages - drug effects
Macrophages - immunology
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - immunology
Autoimmunity
B cell T cells
Dendritic cells
Vitamin D
Neutrophils
Infections
Macrophage
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Summary:Evidence exists for a role for vitamin D and its active metabolites in modulating immune functions. In animal models, vitamin D deficiency is associated with a higher risk for autoimmunity in genetically predisposed subjects and increases in susceptibility to infections. In addition, high-dose vitamin D can improve immune health, prevent autoimmunity, and improve defense against infections. In humans, evidence exists on associations between vitamin D deficiency and impaired immune function, leading to autoimmunity in genetically predisposed people and increased risk for infections; data on therapeutic immune effects of vitamin D supplementation when vitamin D levels are already sufficient are lacking.
ISSN:1558-4410
DOI:10.1016/j.ecl.2017.07.010