Diabetes Mellitus and Cancer Risk in a Network of Case-Control Studies

• Published in: Nutrition and cancer Vol. 64; no. 5; pp. 643 - 651
• Main Authors: Bosetti, Cristina, Rosato, Valentina, Polesel, Jerry, Levi, Fabio, Talamini, Renato, Montella, Maurizio, Negri, Eva, Tavani, Alessandra, Zucchetto, Antonella, Franceschi, Silvia, Corrao, Giovanni, Vecchia, Carlo La
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Group 01.07.2012; Taylor & Francis Ltd; Taylor & Francis (Routledge)
• Subjects: Adult; Aged; Aged, 80 and over; alcoholic beverages; animal ovaries; Breast Neoplasms; Breast Neoplasms - complications; Breast Neoplasms - epidemiology; Cancer; Case-Control Studies; complications; confidence interval; Confounding Factors (Epidemiology); Confounding Factors, Epidemiologic; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Digestive System Neoplasms; Digestive System Neoplasms - complications; Digestive System Neoplasms - epidemiology; education; Endometrial Neoplasms; Endometrial Neoplasms - complications; Endometrial Neoplasms - epidemiology; endometrium; epidemiology; esophagus; Female; hormone replacement therapy; Humans; Italy; Italy - epidemiology; larynx; Life Sciences; liver; Logistic Models; Male; Medical diagnosis; men; Middle Aged; mouth; Mouth Neoplasms; Mouth Neoplasms - complications; Mouth Neoplasms - epidemiology; Multivariate Analysis; neoplasms; oral contraceptives; pancreas; Pharyngeal Neoplasms; Pharyngeal Neoplasms - complications; Pharyngeal Neoplasms - epidemiology; pharynx; postmenopause; Regression analysis; Risk; Risk assessment; Santé publique et épidémiologie; smoking (habit); Switzerland; Switzerland - epidemiology; women; Italy; Switzerland; Adult Aged Aged; 80 and over Breast Neoplasms/complications/epidemiology Case-Control Studies Confounding Factors (Epidemiology) Diabetes Mellitus; Type 2/complications/epidemiology Digestive System Neoplasms/complications/epidemiology Endometrial Neoplasms/complications/epidemiology Female Humans Italy/epidemiology Logistic Models Male Middle Aged Mouth Neoplasms/complications/epidemiology Multivariate Analysis Pharyngeal Neoplasms/complications/epidemiology Risk Switzerland/epidemiology
• ISSN: 0163-5581; 1532-7914; 1532-7914
• DOI: 10.1080/01635581.2012.676141

Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those without-adjusted for major identified confounding factors for the cancers considered through logistic regression models-were significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer.