Interferon induction in swine lymphocyte antigen-defined miniature pigs

• Published in: Research in veterinary science Vol. 58; no. 3; pp. 282 - 283
• Main Authors: Jordan, L.T, Derbyshire, J.B, Mallard, B.A
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.05.1995; Published by Elsevier Ltd
• Subjects: Animals; Antigens, Viral - immunology; Female; Histocompatibility Antigens - immunology; Interferon Inducers - pharmacology; Interferons - biosynthesis; Lymphocytes - immunology; Phenotype; Swine; Swine, Miniature - immunology; Vesicular stomatitis Indiana virus - immunology
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/0034-5288(95)90118-3

Interferon was induced in two groups of swine lymphocyte antigen (SLA)-defined miniature pigs with polyinosinic: polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. The group 1 pigs were low antibody-response phenotypes (SLA a/a, SLA a/c, SLA c/c), and the group 2 pigs were high antibody-response phenotypes (SLA d/d, SLA d/g, SLA g/g). Six hours after induction the antiviral titres were not influenced by the SLA group, but higher titres were observed in females. Higher antiviral titres were found in group 2 pigs before treatment and 24 hours after treatment, and higher titres were found in female pigs. The antiviral titres before and after treatment were also influenced by the sire. Group 2 pigs had lower total leucocyte counts before treatment, and there was a significant reduction in leucocyte numbers in both groups six hours after induction, due mainly to a large reduction in lymphocyte counts.