Signs of Selection in Synonymous Sites of the Mitochondrial Cytochrome b Gene of Baikal Oilfish (Comephoridae) by mRNA Secondary Structure Alterations

Studies over the past decade have shown a significant role of synonymous mutations in posttranscriptional regulation of gene expression, which is particularly associated with messenger RNA (mRNA) secondary structure alterations. Most studies focused on prokaryote genomes and the nuclear genomes of e...

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Published inBioMed research international Vol. 2015; no. 2015; pp. 1 - 8
Main Authors Kirilchik, Sergei V., Sukhanova, Lyubov V., Mamontov, Anatoliy M., Teterina, Veronika I.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2015
Hindawi Limited
Subjects
Animals
Biomedical research
Comephoridae
Comephorus dybowski
Comephorus dybowskii
Cytochrome
Cytochromes b - chemistry
Cytochromes b - genetics
Deoxyribonucleic acid
DNA
Gene expression
Genetic diversity
Genomes
Haplotypes
Mitochondria - enzymology
Mitochondrial DNA
Mutation
Nucleic Acid Conformation
Perciformes - genetics
RNA, Messenger - chemistry
RNA, Messenger - genetics
Lake Baikal
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Summary:Studies over the past decade have shown a significant role of synonymous mutations in posttranscriptional regulation of gene expression, which is particularly associated with messenger RNA (mRNA) secondary structure alterations. Most studies focused on prokaryote genomes and the nuclear genomes of eukaryotes while little is known about the regulation of mitochondrial DNA (mtDNA) gene expression. This paper reveals signs of selection in synonymous sites of the mitochondrial cytochrome b gene (Cytb) of Baikal oilfish or golomyankas (Comephoridae) directed towards altering the secondary structure of the mRNA and probably altering the character of mtDNA gene expression. Our findings are based on comparisons of intraspecific genetic variation patterns of small golomyanka (Comephorus dybowski) and two genetic groups of big golomyanka (Comephorus dybowskii). Two approaches were used: (i) analysis of the distribution of synonymous mutations between weak-AT (W) and strong-GC (S) nucleotides within species and groups in accordance with mutation directions from central to peripheral haplotypes and (ii) approaches based on the predicted mRNA secondary structure.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Peter F. Stadler
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/387913