Visual Information Routes in the Posterior Dorsal and Ventral Face Network Studied with Intracranial Neurophysiology and White Matter Tract Endpoints

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 32; no. 2; pp. 342 - 366
• Main Authors: Babo-Rebelo, M, Puce, A, Bullock, D, Hugueville, L, Pestilli, F, Adam, C, Lehongre, K, Lambrecq, V, Dinkelacker, V, George, N
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 10.01.2022; Oxford University Press (OUP)
• Subjects: Brain Mapping; Cognitive science; Electroencephalography; Humans; Life Sciences; Magnetic Resonance Imaging; Neurons and Cognition; Neurophysiology; Neuroscience; Original; Psychology; Psychology and behavior; Temporal Lobe - diagnostic imaging; Temporal Lobe - physiology; White Matter - diagnostic imaging; face; occipitotemporal cortex; emotion; gaze; iEEG
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhab212

Abstract Occipitotemporal regions within the face network process perceptual and socioemotional information, but the dynamics and information flow between different nodes of this network are still debated. Here, we analyzed intracerebral EEG from 11 epileptic patients viewing a stimulus sequence beginning with a neutral face with direct gaze. The gaze could avert or remain direct, while the emotion changed to fearful or happy. N200 field potential peak latencies indicated that face processing begins in inferior occipital cortex and proceeds anteroventrally to fusiform and inferior temporal cortices, in parallel. The superior temporal sulcus responded preferentially to gaze changes with augmented field potential amplitudes for averted versus direct gaze, and large effect sizes relative to other network regions. An overlap analysis of posterior white matter tractography endpoints (from 1066 healthy brains) relative to active intracerebral electrodes in the 11 patients showed likely involvement of both dorsal and ventral posterior white matter pathways. Overall, our data provide new insight into the timing of face and social cue processing in the occipitotemporal brain and anchor the superior temporal cortex in dynamic gaze processing.