Melanin-concentrating hormone, hippocampal nitric oxide levels and memory retention
The present study attempts to determine, if the effect of melanin-concentrating hormone (MCH) upon memory retention is correlated with changes in nitric oxide synthase (NOS) activity and tissue levels of nitric oxide (NO) and cGMP. We used a behavioral experiment using a step-down inhibitory avoidan...
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Published in | Peptides (New York, N.Y. : 1980) Vol. 23; no. 12; pp. 2213 - 2221 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.12.2002
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Subjects | |
Online Access | Get full text |
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Summary: | The present study attempts to determine, if the effect of melanin-concentrating hormone (MCH) upon memory retention is correlated with changes in nitric oxide synthase (NOS) activity and tissue levels of nitric oxide (NO) and cGMP. We used a behavioral experiment using a step-down inhibitory avoidance test, the biochemical determinations of NO and cGMP, and electrophysiological model. Results of behavioral studies (step-down test) showed that MCH administration reverts the amnesic effects induced by
N
G-nitro-
l-arginine (
l-NOArg). Moreover, electrophysiological studies demonstrated that
l-NOArg did not block the potentiation induced by the peptide. Hippocampal NO and cGMP levels increased after MCH injection. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0196-9781 1873-5169 |
DOI: | 10.1016/S0196-9781(02)00252-8 |