Invasive Nontyphoidal Salmonella Infection in a Patient with Early-Stage Chronic Lymphocytic Leukemia

• Published in: Case reports in infectious diseases Vol. 2017; no. 2017; pp. 1 - 3
• Main Authors: Slawek, Deepika, Louie, Eddie, Dubrovskaya, Yanina
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Antibiotics; Back pain; Blood; Care and treatment; Case Report; Case reports; Case studies; Chemotherapy; Chronic lymphocytic leukemia; Defects; Diagnosis; Family medical history; Gene expression; Hematology; HIV; Human immunodeficiency virus; Immunoglobulins; Infections; Infectious diseases; Leukemia; Lymphatic system; Patients; Pneumonia; Salmonella; Salmonellosis; United States > US
• ISSN: 2090-6625; 2090-6633
• DOI: 10.1155/2017/9091276

We describe a case of a 72-year-old man with early-stage chronic lymphocytic leukemia (CLL) who presented with invasive nontyphoidal Salmonella (iNTS) infection, necrotizing pneumonia, and chronic infection of a hilar lymph node. Infection is a major cause of death in patients with CLL. Though few cases of iNTS infection associated with CLL have been described in the literature, to our knowledge this is the first reported case of iNTS-associated necrotizing pneumonia. Immunocompromised state in patients, even with early-stage CLL, likely predisposes them to invasive infection with intracellular organisms, such as Salmonella spp. In this case, successful treatment was achieved with prolonged course of intravenous followed by oral antibiotics without any surgical removal of infected focus.