Intensive Care Unit Outcomes Among Patients With Lung Cancer in the Surveillance, Epidemiology, and End Results–Medicare Registry

• Published in: Journal of clinical oncology Vol. 30; no. 14; pp. 1686 - 1691
• Main Authors: SLATORE, Christopher G, CECERE, Laura M, LETOURNEAU, Jennifer L, O'NEIL, Maya E, DUCKART, Jonathan P, SOYLEMEZ WIENER, Renda, FARJAH, Farhood, COOKE, Colin R
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 10.05.2012
• Subjects: Age Factors; Aged; Aged, 80 and over; Biological and medical sciences; Cause of Death; Cohort Studies; Combined Modality Therapy; Critical Care - methods; Disease Progression; Disease-Free Survival; Female; Hospital Mortality - trends; Humans; Intensive Care Units - utilization; Logistic Models; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Male; Medical sciences; Medicare; ORIGINAL REPORTS; Pneumology; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Registries; Retrospective Studies; Risk Assessment; SEER Program; Sex Factors; Survival Analysis; Tumors; Tumors of the respiratory system and mediastinum; United States - epidemiology; United States; Human; Lung disease; Health insurance; Prognosis; Respiratory disease; Lung cancer; Malignant tumor; Epidemiology; Intensive care unit; Cancerology; Surveillance; Register; Bronchus disease; Cancer
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2011.40.0846

Lung cancer is the leading cause of cancer-related mortality. Intensive care unit (ICU) use among patients with cancer is increasing, but data regarding ICU outcomes for patients with lung cancer are limited. We used the Surveillance, Epidemiology, and End Results (SEER) -Medicare registry (1992 to 2007) to conduct a retrospective cohort study of patients with lung cancer who were admitted to an ICU for reasons other than surgical resection of their tumor. We used logistic and Cox regression to evaluate associations of patient characteristics and hospital mortality and 6-month mortality, respectively. We calculated adjusted associations for mechanical ventilation receipt with hospital and 6-month mortality. Of the 49,373 patients with lung cancer admitted to an ICU for reasons other than surgical resection, 76% of patients survived the hospitalization, and 35% of patients were alive 6 months after discharge. Receipt of mechanical ventilation was associated with increased hospital mortality (adjusted odds ratio, 6.95; 95% CI, 6.89 to 7.01; P < .001), and only 15% of these patients were alive 6 months after discharge. Of all ICU patients with lung cancer, the percentage of patients who survived 6 months from discharge was 36% for patients diagnosed in 1992 and 32% for patients diagnosed in 2005, whereas it was 16% and 11% for patients who received mechanical ventilation, respectively. Most patients with lung cancer enrolled in Medicare who are admitted to an ICU die within 6 months of admission. To improve patient-centered care, these results should guide shared decision making between patients with lung cancer and their clinicians before an ICU admission.