The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central play...

Full description

Saved in:
Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 10; no. 7; p. 1584
Main Author Alexaki, Vasileia Ismini
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 23.06.2021
MDPI
Subjects
Aging
Alzheimer's disease
Brain
Brain-derived neurotrophic factor
Cytokines
Dyslipidemia
Glucocorticoids
Growth factors
Inflammation
Insulin
Insulin resistance
Life span
Metabolism
Microglia
Neurodegeneration
Neurodegenerative diseases
neuroinflammation
Neuropathology
Obesity
Review
Risk factors
systemic inflammation
Online AccessGet full text

Cover

More Information
Summary:Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10071584