Mesoporous silica nanoparticles engineered for ultrasound-induced uptake by cancer cells

A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is presented here. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shield...

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Bibliographic Details
Published inNanoscale Vol. 10; no. 14; pp. 6402 - 6408
Main Authors Paris, Juan L, Manzano, Miguel, Cabañas, M Victoria, Vallet-Regí, María
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2018
Subjects
Biocompatibility
Biological Transport
Biomedical materials
Cancer
Cell Line, Tumor
Humans
Nanoparticles
Nanoparticles - metabolism
Polyethylene glycol
Polyethylene Glycols
Polymers
Porosity
Porous materials
Silica
Silicon Dioxide
Surface properties
Ultrasonic imaging
Ultrasonic Waves
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Summary:A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is presented here. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively charged surface. This favors the internalization in human osteosarcoma cells, where the release of topotecan takes place, drastically enhancing the cytotoxic effect.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr00693h