The Promoter Region of the Proto-Oncogene MST1R Contains the Main Features of G-Quadruplexes Formation

MST1R (RON) is a receptor of the MET tyrosine kinase receptor family involved in several cancers such as pancreas, breast, ovary, colon, and stomach. Some studies have shown that overexpression of MST1R increases the migratory and invasive properties of cancer cells. The promoter region of the oncog...

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Published inInternational journal of molecular sciences Vol. 23; no. 21; p. 12905
Main Authors Robert, Coralie, Marquevielle, Julien, Salgado, Gilmar F.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2022
MDPI
Subjects
c-Met protein
c-Myc protein
Cancer
Experiments
G-quadruplex
Gene regulation
Kinases
MST1R
Myc protein
NMR
Nuclear magnetic resonance
Oncogenes
Polymorphism
promoter
Protein-tyrosine kinase receptors
Ron protein
Signal transduction
Tyrosine
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Summary:MST1R (RON) is a receptor of the MET tyrosine kinase receptor family involved in several cancers such as pancreas, breast, ovary, colon, and stomach. Some studies have shown that overexpression of MST1R increases the migratory and invasive properties of cancer cells. The promoter region of the oncogene MST1R is enriched in guanine residues that can potentially form G-quadruplexes (G4s), as it was observed in other oncogenic promoters such as KRAS and c-MYC. There is abundant literature that links the presence of G4s in promoter regions of oncogenes to diverse gene regulation processes that are not well understood. In this work, we have studied the reverse and forward sequence of MST1R promoter region using the G4Hunter software and performed biophysical studies to characterize the best scored sequences.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232112905