Investigating the Mechanisms of AquaporinZ Reconstitution through Polymeric Vesicle Composition for a Biomimetic Membrane

Aquaporin-Z (AqpZ) are water channel proteins with excellent water permeability and solute rejection properties. AqpZ can be reconstituted into vesicles utilizing cell-like bilayer membranes assembled from amphiphilic block copolymers, for the preparation of high-performance biomimetic membranes. Ho...

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Bibliographic Details
Published inPolymers Vol. 12; no. 9; p. 1944
Main Authors Zhou, Danhua, Zhou, Hu, Zhou, Shufeng, Tong, Yen Wah
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 28.08.2020
MDPI
Subjects
AqpZ
biomimetic membrane
Biomimetics
Block copolymers
Composition
composition-reconstitution
Copolymers
Desalination
Lipids
Membranes
Molecular weight
Morphology
Permeability
Phase transitions
polymeric vesicles
Polymers
Proteins
Scientific imaging
Temperature
Thermodynamic properties
Thin films
Vesicles
United Kingdom > UK
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Summary:Aquaporin-Z (AqpZ) are water channel proteins with excellent water permeability and solute rejection properties. AqpZ can be reconstituted into vesicles utilizing cell-like bilayer membranes assembled from amphiphilic block copolymers, for the preparation of high-performance biomimetic membranes. However, only a few copolymers have been found suitable to act as the membrane matrix for protein reconstitution. Hence, this work analyzes the mechanism of protein reconstitution based on a composition-reconstitution relationship. The vesicle formation and AqpZ reconstitution processes in various amphiphilic block copolymers were investigated in terms of size, morphology, stability, polymeric bilayer membrane rigidity, and thermal behavior. Overall, this study contributes to the understanding of the composition-reconstitution relationship of biomimetic membranes based on AqpZ-reconstituted polymeric vesicles.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym12091944