Albumin Might Attenuate Bacteria-Induced Damage on Kupffer Cells for Patients with Chronic Liver Disease

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 9; p. 2298
• Main Authors: Lin, Hao, Fan, Yuhui, Wieser, Andreas, Zhang, Jiang, Regel, Ivonne, Nieß, Hanno, Mayerle, Julia, Gerbes, Alexander L., Steib, Christian J.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 03.09.2021; MDPI
• Subjects: Albumin; Bacteria; Bacterial infections; Biobanks; C-reactive protein; Cholangitis; chronic liver diseases; E coli; Endothelial cells; Gene expression; Gram-positive bacteria; hepatic non-parenchymal cells; Hepatitis; Human serum albumin; Immunofluorescence; Immunomodulation; Inflammation; Kinases; Kupffer cells; L-Lactate dehydrogenase; Lactic acid; Liver cirrhosis; Liver diseases; NF-κB protein; Patients; Proteins; Staphylococcus infections; Stellate cells; Streptococcus infections; United States > US; Germany

Chronic liver diseases (CLDs) are complex diseases that cause long-term inflammation and infection, which in turn accelerate their development. The usage of albumin in patients with CLDs has been debated for years. Human serum albumin (HSA) plays a key role in immunomodulation during the process of...