Porous Polymers from High Internal Phase Emulsions as Scaffolds for Biological Applications

High internal phase emulsions (HIPEs), with densely packed droplets of internal phase and monomers dispersed in the continuous phase, are now an established medium for porous polymer preparation (polyHIPEs). The ability to influence the pore size and interconnectivity, together with the process scal...

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Bibliographic Details
Published inPolymers Vol. 13; no. 11; p. 1786
Main Authors Kramer, Stanko, Cameron, Neil R., Krajnc, Peter
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 28.05.2021
MDPI
Subjects
Architecture
Biocompatibility
biodegradable polymers
Biomedical materials
cell culturing
Cell growth
Cytotoxicity
Emulsion polymerization
emulsion templating
Life expectancy
Mechanical properties
Morphology
Physiology
polyHIPE
Polymers
Pore size
Porous media
porous polymers
Review
Scaffolds
Surfactants
Tissue engineering
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Summary:High internal phase emulsions (HIPEs), with densely packed droplets of internal phase and monomers dispersed in the continuous phase, are now an established medium for porous polymer preparation (polyHIPEs). The ability to influence the pore size and interconnectivity, together with the process scalability and a wide spectrum of possible chemistries are important advantages of polyHIPEs. In this review, the focus on the biomedical applications of polyHIPEs is emphasised, in particular the applications of polyHIPEs as scaffolds/supports for biological cell growth, proliferation and tissue (re)generation. An overview of the polyHIPE preparation methodology is given and possibilities of morphology tuning are outlined. In the continuation, polyHIPEs with different chemistries and their interaction with biological systems are described. A further focus is given to combined techniques and advanced applications.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym13111786