Validation of the Mandarin Chinese version of the Leicester Cough Questionnaire in bronchiectasis

• Published in: The international journal of tuberculosis and lung disease Vol. 18; no. 12; pp. 1431 - 1437
• Main Authors: Gao, Y-H., Guan, W-J., Xu, G., Gao, Y., Lin, Z-Y., Tang, Y., Lin, Z-M., Li, H-M., Luo, Q., Zhong, N-S., Birring, S. S., Chen, R-C.
• Format: Journal Article
• Language: English
• Published: Paris International Union Against Tuberculosis and Lung Disease 01.12.2014; International Union against Tuberculosis and Lung Disease
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Asian Continental Ancestry Group - psychology; Bacterial diseases; Biological and medical sciences; Bronchiectasis; Bronchiectasis - diagnosis; Bronchiectasis - drug therapy; Bronchiectasis - ethnology; Bronchiectasis - psychology; China - epidemiology; Cough; Cultural Characteristics; Disease Progression; Female; Health Status; Health Status Indicators; Human bacterial diseases; Humans; Infectious diseases; Lcq; Male; Medical sciences; Middle Aged; Pneumology; Predictive Value of Tests; Prospective Studies; Quality Of Life; Reproducibility of Results; Respiratory system : syndromes and miscellaneous diseases; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Translating; Treatment Outcome; Tuberculosis and atypical mycobacterial infections; Validity; Asia; China; Human; Test validation; Validity; Asiatic; Questionnaire; Respiratory disease; Bronchus disease; Chinese; Bronchiectasis; LCQ; Cough; Quality of life
• ISSN: 1027-3719; 1815-7920
• DOI: 10.5588/ijtld.14.0195

BACKGROUND: The Leicester Cough Questionnaire (LCQ) has been validated for assessing cough-specific health status in bronchiectasis. We translated the LCQ into Mandarin Chinese and investigated its validity, reliability and responsiveness.METHODS: The LCQ was translated into Mandarin Chinese using the forward-backward translation procedure. A total of 144 out-patients completed the Mandarin Chinese version of the LCQ (LCQ-MC), the Hospital Anxiety and Depression Scale (HADS) and the St George's Respiratory Questionnaire. Reassessments were performed during exacerbations and at 6 months. Concurrent validation, internal consistency, repeatability and responsiveness were determined.RESULTS: Minor cultural adaptations were made to the wording of LCQ-MC. No other difficulties were found during the translation process, with all items easily adapted to acceptable Mandarin Chinese. The questionnaire was not changed in terms of content layout and the order of the questions. In cognitive debriefing interviews, participants reported that the questionnaire was acceptable, relevant, comprehensive and easy to complete. The LCQ-MC showed good concurrent validity, internal consistency and test-retest reliability. Responsiveness was shown by significant changes in LCQ-MC scores between steady state, the first exacerbation and following 2-week antibiotic treatment (both interval changes, P < 0.01)CONCLUSION: The LCQ-MC is a valid, reliable and responsive instrument for determining cough-specific health status in Chinese bronchiectasis patients.