Methods for screening tumors for p53 status and therapeutic exploitation

Mutations in the p53 oncosuppressor gene occur in most human cancers and regulation of the protein is defective in a variety of others. Novel strategies are emerging for the treatment of tumors that have p53 mutations. In this context, the analysis of p53 status is useful in diagnosis and prognosis,...

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Published inExpert review of molecular diagnostics Vol. 3; no. 3; pp. 289 - 301
Main Authors Tullo, Apollonia, D'Erchia, Anna Maria, Sbisà, Elisabetta
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.05.2003
Taylor & Francis
Subjects
Animals
Cancer
gene therapy
Genes, p53 - genetics
Genetic Testing
Genetic Therapy - methods
Humans
microarray
Models, Biological
molecular diagnosis
Mutation
mutation detection
Neoplasms - genetics
Neoplasms - therapy
Nuclear Proteins
p53 protein
Prognosis
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-mdm2
Reviews
sequencing
small peptides
Tumor Suppressor Protein p53 - genetics
Tumors
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Summary:Mutations in the p53 oncosuppressor gene occur in most human cancers and regulation of the protein is defective in a variety of others. Novel strategies are emerging for the treatment of tumors that have p53 mutations. In this context, the analysis of p53 status is useful in diagnosis and prognosis, and could serve to evaluate the effectiveness of a cancer treatment. In this review, we report an overview of major methods for screening tumors for p53 status and the major strategies suggested for restoring p53 function.
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ISSN:1473-7159
1744-8352
DOI:10.1586/14737159.3.3.289