Methods for screening tumors for p53 status and therapeutic exploitation
Mutations in the p53 oncosuppressor gene occur in most human cancers and regulation of the protein is defective in a variety of others. Novel strategies are emerging for the treatment of tumors that have p53 mutations. In this context, the analysis of p53 status is useful in diagnosis and prognosis,...
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Published in | Expert review of molecular diagnostics Vol. 3; no. 3; pp. 289 - 301 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
Informa Healthcare
01.05.2003
Taylor & Francis |
Subjects | |
Online Access | Get full text |
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Summary: | Mutations in the p53 oncosuppressor gene occur in most human cancers and regulation of the protein is defective in a variety of others. Novel strategies are emerging for the treatment of tumors that have p53 mutations. In this context, the analysis of p53 status is useful in diagnosis and prognosis, and could serve to evaluate the effectiveness of a cancer treatment. In this review, we report an overview of major methods for screening tumors for p53 status and the major strategies suggested for restoring p53 function. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 1473-7159 1744-8352 |
DOI: | 10.1586/14737159.3.3.289 |