Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls

Neurotrophins like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to play an important role in neuronal repair and plasticity. Recent experimental evidence suggests neuroprotective effects of these proteins in multiple sclerosis (MS). We investigated the response...

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Published inJournal of neuroimmunology Vol. 138; no. 1; pp. 99 - 105
Main Authors Gold, Stefan M., Schulz, Karl-Heinz, Hartmann, Sten, Mladek, Mila, Lang, Undine E., Hellweg, Rainer, Reer, Rüdiger, Braumann, Klaus-Michael, Heesen, Christoph
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2003
Subjects
Adult
Age Factors
Analysis of Variance
BDNF
Brain-Derived Neurotrophic Factor - blood
Exercise
Exercise Test - standards
Exercise Test - statistics & numerical data
Female
Heart Rate
Humans
Lactic Acid - blood
Male
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - physiopathology
Nerve Growth Factor - blood
Neuroprotection
NGF
Sex Factors
Time Factors
Neuroprotection
Multiple sclerosis
Exercise
NGF
BDNF
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Summary:Neurotrophins like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to play an important role in neuronal repair and plasticity. Recent experimental evidence suggests neuroprotective effects of these proteins in multiple sclerosis (MS). We investigated the response of serum NGF and BDNF concentrations to standardized acute exercise in MS patients and controls. Basal NGF levels were significantly elevated in MS. Thirty minutes of moderate exercise significantly induced BDNF production in MS patients and controls, but no differential effects were seen. We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently.
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ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(03)00121-8