The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance

• Published in: Neurosurgery clinics of North America Vol. 32; no. 2; p. 171
• Main Authors: Leelatian, Nalin, Hong, Christopher S, Bindra, Ranjit S
• Format: Journal Article
• Language: English
• Published: United States 01.04.2021
• Subjects: TMZ; MSI; GBM; MMR; MGMT; Alkylators; TMB

Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, t...