The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance

Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, t...

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Bibliographic Details
Published inNeurosurgery clinics of North America Vol. 32; no. 2; p. 171
Main Authors Leelatian, Nalin, Hong, Christopher S, Bindra, Ranjit S
Format Journal Article
LanguageEnglish
Published United States 01.04.2021
Subjects
TMZ
MSI
GBM
MMR
MGMT
Alkylators
TMB
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Summary:Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, the authors review key concepts in the molecular mechanisms of MMR in response to alkylation damage, approaches to detect MMR status in the clinic, and the clinical relevance of this pathway in glioblastoma multiforme treatment response and resistance.
ISSN:1558-1349
DOI:10.1016/j.nec.2020.12.009