The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance
Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, t...
Saved in:
| Published in | Neurosurgery clinics of North America Vol. 32; no. 2; p. 171 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.04.2021
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, the authors review key concepts in the molecular mechanisms of MMR in response to alkylation damage, approaches to detect MMR status in the clinic, and the clinical relevance of this pathway in glioblastoma multiforme treatment response and resistance. |
|---|---|
| AbstractList | Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base substitution and insertion-deletion mismatches, which primarily arise from replication errors that escape DNA polymerase proof-reading function. Here, the authors review key concepts in the molecular mechanisms of MMR in response to alkylation damage, approaches to detect MMR status in the clinic, and the clinical relevance of this pathway in glioblastoma multiforme treatment response and resistance. |
| Author | Leelatian, Nalin Hong, Christopher S Bindra, Ranjit S |
| Author_xml | – sequence: 1 givenname: Nalin surname: Leelatian fullname: Leelatian, Nalin organization: Department of Pathology, Yale School of Medicine, 310 Cedar Street LH 108, New Haven, CT 06510, USA – sequence: 2 givenname: Christopher S surname: Hong fullname: Hong, Christopher S organization: Department of Neurosurgery, Yale School of Medicine, 333 Cedar Street Tompkins 4, New Haven, CT 06510, USA – sequence: 3 givenname: Ranjit S surname: Bindra fullname: Bindra, Ranjit S email: Ranjit.bindra@yale.edu organization: Department of Therapeutic Radiology, Yale School of Medicine, 333 Cedar Street Hunter 2, New Haven, CT 06510, USA. Electronic address: Ranjit.bindra@yale.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33781500$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j8tKAzEYRoMo9qIP4EbyAjP-ucxtKUWr0CKUEdyVTPKHpswkwyRd-PZWqqvDgcMH34Jc--CRkAcGOQNWPh1zjzrnwM_Oc4DmisxZUdQZE7KZkUWMRwBRAWO3ZCZEVbMCYE6-2gPSXeiRBku3Lg4q6QPd4ajcRJ2n696FrlcxhUHR7alPzoZpQNpOqNKAPp3bOAYfkSpvfsXFpLzGO3JjVR_x_o9L8vn60q7ess3H-n31vMm0LOqU1cZU0lZoNUptobKWo-BGceiMQQGKKWsla5TsOAhgmpdQik4iL7hFUfIlebzsjqduQLMfJzeo6Xv_f5H_ALCJVQ0 |
| CitedBy_id | crossref_primary_10_1002_cpz1_70097 crossref_primary_10_1186_s12885_023_10937_9 crossref_primary_10_1186_s11658_024_00547_z crossref_primary_10_1093_noajnl_vdab177 crossref_primary_10_1126_science_abn7570 crossref_primary_10_3390_diagnostics13111949 crossref_primary_10_3390_cancers14225494 crossref_primary_10_3390_ijms23137474 crossref_primary_10_1093_neuonc_noac207 crossref_primary_10_3390_cimb46070412 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2020 Elsevier Inc. All rights reserved. |
| DBID | NPM |
| DOI | 10.1016/j.nec.2020.12.009 |
| DatabaseName | PubMed |
| DatabaseTitle | PubMed |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1558-1349 |
| ExternalDocumentID | 33781500 |
| Genre | Journal Article Review |
| GroupedDBID | --- -RU .1- .FO .GJ 0R~ 123 1P~ 4.4 457 4CK 53G 5RE AAEDT AAEDW AALRI AAQQT AAWTL AAXUO ABFRF ABJNI ABMAC ABQZK ADBBV AEFWE AENEX AEVXI AFCTW AFETI AFRHN AFTJW AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ ASTAF AXIYT B08 COIAO CS3 DAHGL DU5 EBS EJD F5P FDB HZ~ NPM O9- OQ- PG~ SEL SES UDS UNMZH Z5R |
| ID | FETCH-LOGICAL-c458t-8dd74f7efce4cf07ff2e32da20bdde30a1aff419a4b20301c26063b4e252fe362 |
| IngestDate | Thu Jan 02 22:58:01 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | TMZ MSI GBM MMR MGMT Alkylators TMB |
| Language | English |
| License | Copyright © 2020 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c458t-8dd74f7efce4cf07ff2e32da20bdde30a1aff419a4b20301c26063b4e252fe362 |
| PMID | 33781500 |
| ParticipantIDs | pubmed_primary_33781500 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-01 |
| PublicationDateYYYYMMDD | 2021-04-01 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Neurosurgery clinics of North America |
| PublicationTitleAlternate | Neurosurg Clin N Am |
| PublicationYear | 2021 |
| SSID | ssj0037011 |
| Score | 2.3264906 |
| SecondaryResourceType | review_article |
| Snippet | Mismatch repair (MMR) is a highly conserved DNA repair pathway that is critical for the maintenance of genomic integrity. This pathway targets base... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 171 |
| Title | The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33781500 |
| Volume | 32 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEA6rgngRxfeLHLwtlTZNH3tUURdBD7LC3iRP7KJd0Z7EH--kSdq6Kj4upTS0lM7XyTeTbyYIHTKWpZzLPIgHQgeUZ2mQDyQJNB8wARMEvLxJ6F9dp8NbejlOxr3eW7e6pOJH4vXLupL_WBWugV1NlewfLNs8FC7AOdgXjmBhOP7axjdOHnhVvAD5FPeGUrPCiMz7Fw_FlAM7rqaPrF9X2hqGqvqjRlx-YxWyypUpvhgy6VEw8X2dTMNLWzzt6ihr9ceHBZ-OrMdo62xS9RoofgO9oZP-dpoZtFnXk6KUz5bFsnJSVG7EJSNI1NGwKOdAE4hKY9uG1HvYNoPZBLrWXUZ2-5VPbtxmFCZHpTJdJklYZ2zrNgpVx6xPj7Vd4zjLgdaGP4_OdNb2Q3NoDmIMs2mqyfTYWTzOwPH5VfBaDzjzLkto0d8_E5HUzGS0gpZdSIGPLT5WUU-Va2gM2MAGG3iqsccGttjARYm72MAtNnCDDeyxgQEbuMXGOro9PxudDgO3i0YgaJJXQS5lRnWmtFBU6DDTmqiYSEZCDlNbHLKIaU2jAaOcmPhYQISbxpwqkhCtgN9soPlyWqothBMJ9FACodRAQqOUMJURmfNEpBCX0kRso037Ie6ebKuUO_-Jdr4d2UVLLZD20IKGf1PtA9Gr-EFtkXdAGFWW |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+Mismatch+Repair+in+Glioblastoma+Multiforme+Treatment+Response+and+Resistance&rft.jtitle=Neurosurgery+clinics+of+North+America&rft.au=Leelatian%2C+Nalin&rft.au=Hong%2C+Christopher+S&rft.au=Bindra%2C+Ranjit+S&rft.date=2021-04-01&rft.eissn=1558-1349&rft.volume=32&rft.issue=2&rft.spage=171&rft_id=info:doi/10.1016%2Fj.nec.2020.12.009&rft_id=info%3Apmid%2F33781500&rft_id=info%3Apmid%2F33781500&rft.externalDocID=33781500 |