Autophagy controls carbon, nitrogen, and redox homeostasis in plants

During leaf senescence, autophagy is essential for nutrient recycling and remobilization, and for plant productivity. Metabolome and transcriptome studies performed on autophagy mutants revealed major disorders in nitrogen, carbon, and redox metabolisms. Analysis showed that autophagy mutants are de...

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Published inAutophagy Vol. 12; no. 5; pp. 896 - 897
Main Author Masclaux-Daubresse, C.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 03.05.2016
Subjects
Anthocyanin
Arabidopsis - metabolism
Autophagic Puncta
Autophagy - physiology
Carbon - metabolism
Gene Expression Regulation, Plant
Homeostasis - physiology
Life Sciences
metabolism
metabolome
Nitrogen - metabolism
Oxidation-Reduction
Plant Proteins - metabolism
plant senescence
transcriptome
Anthocyanin
plant senescence
metabolism
transcriptome
metabolome
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Summary:During leaf senescence, autophagy is essential for nutrient recycling and remobilization, and for plant productivity. Metabolome and transcriptome studies performed on autophagy mutants revealed major disorders in nitrogen, carbon, and redox metabolisms. Analysis showed that autophagy mutants are depleted of antioxidant anthocyanin molecules. Transcriptome analysis revealed that the depletion of anthocyanin is due to the downregulation of the master genes encoding the enzymes and regulatory proteins involved in the flavonoid pathway. The hyperaccumulation of salicylic acid and the depletion of anthocyanin in autophagy mutants might result from the rerouting of carbon resources in the phenylpropanoid pathway and amplify oxidative stress in autophagy mutants.
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PMCID: PMC4854538
Punctum to: Masclaux-Daubresse C, Clément G, Anne P, Routaboul J, Guiboileau A, Soulay F, Shirasu K, Yoshimoto K. Stitching together the multiple dimensions of autophagy using metabolomic and transcriptomic analyses reveals new impacts of autophagy defects on metabolism, development, and plant response to environment. Plant Cell 26: 1857–1877
Color versions for one or more of the figures in the article can be found online at www.tandfonline.com/kaup.
ISSN:1554-8627
1554-8635
DOI:10.4161/auto.36261