Rodent Models of Post-Stroke Dementia

Post-stroke cognitive impairment is one of the most common complications in stroke survivors. Concomitant vascular risk factors, including aging, diabetes mellitus, hypertension, dyslipidemia, or underlying pathologic conditions, such as chronic cerebral hypoperfusion, white matter hyperintensities,...

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Published inInternational journal of molecular sciences Vol. 23; no. 18; p. 10750
Main Authors Kim, Hahn Young, Back, Dong Bin, Choi, Bo-Ryoung, Choi, Dong-Hee, Kwon, Kyoung Ja
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 15.09.2022
MDPI
Subjects
Aging
Alzheimer's disease
amyloid deposits
Animal cognition
Animal models
Carotid arteries
chronic cerebral hypoperfusion
Cognitive ability
Comorbidity
Dementia
Dementia disorders
Diabetes
Diabetes mellitus
Dyslipidemia
Experiments
Hypertension
intracerebral hemorrhage
ischemic stroke
Literature reviews
Neurodegeneration
Pathology
Pathophysiology
post-stroke dementia
Review
Risk analysis
Risk factors
rodent model
Rodents
Stroke
Substantia alba
Surgical techniques
Veins & arteries
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Summary:Post-stroke cognitive impairment is one of the most common complications in stroke survivors. Concomitant vascular risk factors, including aging, diabetes mellitus, hypertension, dyslipidemia, or underlying pathologic conditions, such as chronic cerebral hypoperfusion, white matter hyperintensities, or Alzheimer’s disease pathology, can predispose patients to develop post-stroke dementia (PSD). Given the various clinical conditions associated with PSD, a single animal model for PSD is not possible. Animal models of PSD that consider these diverse clinical situations have not been well-studied. In this literature review, diverse rodent models that simulate the various clinical conditions of PSD have been evaluated. Heterogeneous rodent models of PSD are classified into the following categories: surgical technique, special structure, and comorbid condition. The characteristics of individual models and their clinical significance are discussed in detail. Diverse rodent models mimicking the specific pathomechanisms of PSD could provide effective animal platforms for future studies investigating the characteristics and pathophysiology of PSD.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810750