Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population

• Published in: Biochemical and biophysical research communications Vol. 302; no. 4; pp. 751 - 758
• Main Authors: Daimon, Makoto, Ji, Guijin, Saitoh, Tamotsu, Oizumi, Toshihide, Tominaga, Makoto, Nakamura, Takahiro, Ishii, Keisuke, Matsuura, Tadashi, Inageda, Kiyoshi, Matsumine, Hiroto, Kido, Takashi, Htay, Lwin, Kamatani, Naoyuki, Muramatsu, Masaaki, Kato, Takeo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.03.2003
• Subjects: Adjusted for TG and BMI; Aged; ATP-Binding Cassette Transporters; Carrier Proteins - genetics; Case-Control Studies; Diabetes Mellitus, Type 2 - genetics; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Genetic Predisposition to Disease; Genetics, Population; Genotype; Hepatocyte growth factor receptor; Humans; Japan; Male; Neoplasm Proteins; Nested case-control study; No stratification; Polymorphism, Single Nucleotide; Potassium Channels - genetics; Potassium Channels, Inwardly Rectifying; Receptors, Drug - genetics; Sulfonylurea Receptors; Tumor Suppressor Proteins; No stratification; Nested case-control study; Hepatocyte growth factor receptor; Adjusted for TG and BMI
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/S0006-291X(03)00248-1

The etiology of type 2 diabetes (DM) is polygenic. We investigated here genes and polymorphisms that associate with DM in the Japanese population. Single-nucleotide polymorphisms (SNPs) of 398 derived from 120 candidate genes were examined for association with DM in a population-based case-control study. The study group consisted of 148 cases and 227 controls recruited from Funagata, Japan. No evident subpopulation structure was detected for the tested population. The association tests were conducted with standard allele positivity tables ( χ 2 tests) between SNP genotype frequency and case-control status. The independent association of the SNPs from serum triglyceride levels and body mass index was examined by multiple logistic regression analysis. A value of P<0.01 was accepted as statistically significant. Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM.