Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones
Cytochrome P450 cDNAs, AFNS2 and TFNS5, were isolated from snapdragon and torenia petal cDNA libraries, respectively, based on the sequence homology with licorice CYP93B1 cDNA encoding (2S)-flavanone 2-hydroxylase. They were expressed in yeast and identified to encode flavone synthase II catalyzing...
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| Published in | Plant and cell physiology Vol. 40; no. 11; pp. 1182 - 1186 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Oxford University Press
01.11.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Cytochrome P450 cDNAs, AFNS2 and TFNS5, were isolated from snapdragon and torenia petal cDNA libraries, respectively, based on the sequence homology with licorice CYP93B1 cDNA encoding (2S)-flavanone 2-hydroxylase. They were expressed in yeast and identified to encode flavone synthase II catalyzing direct conversion of flavanones to flavones probably via 2-hydroxyflavanones. |
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| AbstractList | Cytochrome P450 cDNAs, AFNS2 and TFNS5, were isolated from snapdragon and torenia petal cDNA libraries, respectively, based on the sequence homology with licorice CYP93B1 cDNA encoding (2S)-flavanone 2-hydroxylase. They were expressed in yeast and identified to encode flavone synthase II catalyzing direct conversion of flavanones to flavones probably via 2-hydroxyflavanones. |
| Author | Kusumi, T Tanaka, Y Aoki, T Akashi, T. (Nihon Univ., Tokyo (Japan)) Yonekura Sakakibara, K Ayabe, S Ueyama, Y Fukuchi Mizutani, M |
| Author_xml | – sequence: 1 fullname: Akashi, T. (Nihon Univ., Tokyo (Japan)) – sequence: 2 fullname: Fukuchi Mizutani, M – sequence: 3 fullname: Aoki, T – sequence: 4 fullname: Ueyama, Y – sequence: 5 fullname: Yonekura Sakakibara, K – sequence: 6 fullname: Tanaka, Y – sequence: 7 fullname: Kusumi, T – sequence: 8 fullname: Ayabe, S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10635120$$D View this record in MEDLINE/PubMed |
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| Snippet | Cytochrome P450 cDNAs, AFNS2 and TFNS5, were isolated from snapdragon and torenia petal cDNA libraries, respectively, based on the sequence homology with... |
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| SubjectTerms | (2S)-flavanone 2-hydroxylase Amino Acid Sequence Antirrhinum majus BIOSINTESIS BIOSYNTHESE BIOSYNTHESIS Catalysis cDNA cloning CITOCROMO P450 CLONACION MOLECULAR CLONAGE MOLECULAIRE Cloning, Molecular Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism CYTOCHROME P450 flavanones flavone synthase Flavone synthase II flavones Flavonoid biosynthesis FLAVONOIDE FLAVONOIDES FLAVONOIDS Flavonoids - biosynthesis Flavonoids - metabolism Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism MOLECULAR CLONING Molecular Sequence Data Phylogeny Plants - enzymology Plants - genetics Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Snapdragon Substrate Specificity Torenia |
| Title | Molecular cloning and biochemical characterization of a novel cytochrome P450, flavone synthase II, that catalyzes direct conversion of flavanones to flavones |
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