Synthesis and Cytostatic Activity of some Pregna-D′-Pentaranes on HeLa Cell Culture

The effects of nine new pregnane steroids containing substituents in the 16α,17α- and/or 3-, 6-, and 19-positions of the steroid framework on the viability of HeLa cervical cancer cells were studied. It was shown that the 6-oximes of 3-keto- and 3-hydroxy-4-dehydrosteroids with a 16α,17α-cyclohexane...

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Published inPharmaceutical chemistry journal Vol. 48; no. 6; pp. 363 - 367
Main Authors Semeikin, A. V., Fedotcheva, T. A., Levina, I. S., Kulikova, L. E., Zavarzin, I. V., Tikhonov, D. A., Kareva, E. N., Shimanovskii, N. L.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.09.2014
Springer
Subjects
Carbocyclic compounds
Cervical cancer
Cyclohexane
Estrogen
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Search for New Drugs
HeLa
MTT
progesterone
pregna-D′-pentaranes
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Summary:The effects of nine new pregnane steroids containing substituents in the 16α,17α- and/or 3-, 6-, and 19-positions of the steroid framework on the viability of HeLa cervical cancer cells were studied. It was shown that the 6-oximes of 3-keto- and 3-hydroxy-4-dehydrosteroids with a 16α,17α-cyclohexane substituent and 3-keto-4-dehydrosteroids with a 16α,17α-phenylcyclopropane substituent reduced the viability of the cell culture. Compound K1047 had the highest cytostatic effect and was promising as a potential hormonal antitumor agent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1111-x