Formats for combinatorial synthesis: solid-phase, liquid-phase and surface

• Published in: Current Opinion in Chemical Biology Vol. 6; no. 3; pp. 339 - 346
• Main Authors: Boyle, Nicholas A, Janda, Kim D
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2002
• Subjects: Combinatorial Chemistry Techniques - methods; Combinatorial synthesis; liquid phase; polymer support 8; solid-phase; surface synthesis; polymer support 8; Chemical Biology; Combinatorial synthesis; surface synthesis; solid-phase; liquid phase
• ISSN: 1367-5931; 1879-0402
• DOI: 10.1016/S1367-5931(02)00308-3

Methods for combinatorial and parallel synthesis continue to evolve in order to meet the demands of modern synthetic organic chemistry. The nature of the support, while typically overlooked, is a key consideration for successful combinatorial organic synthesis. Developments in combinatorial synthesis technologies such as the ‘lab-on-a-chip’ concept and 96-well-plate-compatible resin plugs have been reported, which should contribute to meeting the increasing challenges of this field. Methods for combinatorial and parallel synthesis continue to evolve in order to meet the demands of modern synthetic organic chemistry. The nature of the support, while typically overlooked, is a key consideration for successful combinatorial organic synthesis.